SSBH 2023

Day 2 May 19(Fri) 09:00-10:00	Oral Presentation 1 [Clinical] E Room 1

Chair(s): Kyuri Hwang (Seoul National University, Korea), Ji-Wan Kim (University of Ulsan, Korea)

09:00-09:10	Imminent Fracture Prediction Using Hip Computational Tomography-Based 2.5-Dimensional Deep-Learning Algorithm Sung Hye Kong (Seoul National University, Korea)
09:10-09:20	Fracture Risk Prediction and Assessment from 2D-DXA Scan by Augmented Gradient Boosting Algorithm Heesun Choi (Ewha Womans University, Korea)
09:20-09:30	Development of Mini K-FRAX Tool to Predict Imminent Risk of Fractures in Korean Elderly Women So Young Park (Kyung Hee University, Korea)
09:30-09:40	Association between Frailty and the Risk of Osteoporotic Fracture: The Chungju Metabolic Disease Cohort Study Jeongmin Lee (The Catholic University of Korea, Korea)
09:40-09:50	Genetically Determined Caffeine Intake and Bone Mineral Density: A Two-Sample Mendelian Randomization Study Gloria Hoi-Yee Li (The Hong Kong Polytechnic University, Hong Kong)
09:50-10:00	Associations between Use of Anti-Resorptive Agents for Patients with Osteoporosis and All-Cause Mortality Risk: A Nationwide Population-Based Study Kyoung Jin Kim (Korea University, Korea)

Day 2 May 19(Fri) 09:00-10:00	Oral Presentation 2 [Basic] E Room 2

Chair(s): Wonbong Lim (Chosun University, Korea), Ok Hee Jeon (Korea University, Korea)

09:00-09:11	Mitochondrial Dynamics during Muscle Calcification Joonho Suh (Seoul National University, Korea)
09:11-09:22	A Novel Two-Photon Fluorogenic Probes for Intravital Monitoring of Cathepsin K Activity in Vivo Seyoung Koo (Korea University, Korea)
09:22-09:33	The Role of Endosomal RANKL-LGR4 Signaling during Osteoclast Differentiation Beomchang Kim (Chosun University Hospital, Korea)
09:33-09:44	IL-17 Producing γδ T Cells are Implicated in Bone Loss and Muscle Dysfunction in Mouse Model and Human with Thyrotoxicosis Ho Yeop Lee (Chungnam National University, Korea)

Day 2 May 19(Fri) 09:00-10:00	Working Group 1. Muscle Working Group K Sarcopenia in Korea - Establishing Clinical Practice Guidelines Room 3

Chair(s): Jae-Young Lim (Seoul National University, Korea)

09:00-09:20	Korean Working Group on Sarcopenia Guideline: Expert Consensus on Sarcopenia Screening and Diagnosis by the Korean Society of Sarcopenia, the Korean Society for Bone and Mineral Research, and the Korean Geriatrics Society Ji Yeon Baek (University of Ulsan, Korea)
09:20-09:40	Establishment of Sarcopenia Intervention Guideline for Older Koreans Hee-Won Jung (University of Ulsan, Korea)
09:40-10:00	Clinical Implications and Management for Osteosarcopenia Namki Hong (Yonsei University, Korea)

Day 2 May 19(Fri) 09:00-10:00	Working Group 2. Dental and Craniofacial Working Group K Young Dental Frontiers for Bone Studies Room 4

Chair(s): Jeong Keun Lee (Ajou University, Korea)

09:00-09:20	Implication of Bone Biology to FEA Model for Dental Implant and Alveolar Bone Youngjae Yoon (Kyung Hee University, Korea)
09:20-09:40	Osteoimmunological Understanding for Success and Failure of Dental Implant Joo-Young Park (Seoul National University, Korea)
09:40-10:00	Monocytic Myeloid-Derived Suppressor Cells (M-MDSCs) Expansion and Osteoclastogenic Potential in Obesity-Associated Periodontal Disease Kyu Hwan Kwack (Kyung Hee University, Korea)

Day 2 May 19(Fri) 10:05-10:55	Plenary Lecture 1 E Room 1

We invited Dr. David Rowe (Director of the Center for Regenerative Medicine and Skeletal Development at the University of Connecticut) to be a basic science keynote speaker at SSBH 2023. Dr. Rowe is a distinguished researcher whose work has significantly influenced the development of bone, cartilage, and tendon through cellular differentiation. He has created and generously donated multiple bone cell-specific fluorescent protein-expressing mice, including osteocalcin- and Col1a1-GFP mice, which have become indispensable resources for researchers in skeletal biology. In addition, Dr. Rowe is leading the University of Connecticut's Bonebase program, which provides a platform for sharing his mouse phenotyping big data, mouse lines, and methodologies with other researchers.
Dr. Rowe’s research impacted the cellular differentiation of bone, cartilage, and tendon development. In particular, he has created and donated multiple bone cell-specific fluorescent protein-expressing mice such as osteocalcin- and Col1a1- GFP mice, which are crucial resources for skeletal biology researchers. Dr. Rowe spearheads the University of Connecticut’s Bonebase program to share his mouse phenotyping big data, mouse lines and methodologies.

Chair(s): Hyun-Mo Ryoo (Seoul National University, Korea)

10:05-10:55	Preparing Basic Skeletal Biology Research for the Big Data Arena David W. Rowe (University of Connecticut, USA)

Day 2 May 19(Fri) 11:10-12:25	Symposium 1. Bone Health at Different Stages of Life E Room 1

Jung Sub Lim from Korea Cancer Center Hospital will introduce the practice guidelines for optimizing bone health in Korean children and adolescents which published on 2022 by the Committee on Pediatric Bone Health of the Korean Society of Pediatric Endocrinology.
These guidelines include processes of bone acquisition, definition, and evaluation of low bone mineral density (BMD), causes of osteoporosis, methods for optimizing bone health, and pharmacological treatments for enhancing BMD in children and adolescent.
Adi Cohen from Columbia University will introduce dilemmas commonly encountered in diagnosis, investigation, and management of osteoporosis in younger adults. She will introduce a suggested framework, based on the limited available evidence and supported by clinical experience, for the diagnosis, assessment, and management of osteoporosis in young adults. Youn-Jee Chung will introduce the role of hormone therapy in postmenopausal women in clinical setting. We hope this session will provide an opportunity to share an overall approach and management know-how for lifelong bone health.

Chair(s): Deog Yoon Kim (Kyung Hee University, Korea), Jung-Ho Shin (Korea University, Korea)

11:10-11:35	Clinical Practice Guidelines for Optimizing Bone Health in Korean Children and Adolescents Jung Sub Lim (Korea Cancer Center Hospital, Korea)
11:35-12:00	Dilemmas in the Management of Osteoporosis in Younger Adults Adi Cohen (Columbia University, USA)
12:00-12:25	The Role of Hormone Therapy in Postmenopausal Women Youn-Jee Chung (The Catholic University of Korea, Korea)

Day 2 May 19(Fri) 11:10-12:25	Symposium 2. KSBMR-KMPC Joint Symposium E Room 2

Chair(s): Nacksung Kim (Chonnam National University, Korea), Jung-Eun Kim (Kyungpook National University, Korea)

11:10-11:35	Role of Phospholipase D in Skeletal Tissues Je-Yong Choi (Kyungpook National University, Korea)
11:35-12:00	Multimodal Imaging for the Multi-Models of Skeletal Formation and Regeneration David W. Rowe (University of Connecticut, USA)
12:00-12:25	Mining Molecular Signatures of Osteoregulatory Cells Dong-Guk Shin (University of Connecticut, USA)

Day 2 May 19(Fri) 11:10-12:00	Meet the Expert 1 E Room 3

11:10-12:00	About Large Cohort Studies: Examples about Biomarkers of Aging Steven R. Cummings (San Francisco Coordinating Center, California Pacific Medical Center Research Institute, USA)

Day 2 May 19(Fri) 12:25-12:40	Luncheon Symposium 1 E Room 1

Chair(s): Dong Won Byun (Soonchunhyang University, Korea)

12:25-12:40	The Fast Path in Osteoporosis Treatment, Correcting the Course A Ram Hong (Chonnam National University, Korea)

Day 2 May 19(Fri) 13:25-14:40	KSBMR-ASBMR-JSBMR Joint Symposium E Room 1

We are pleased to announce that the 2023 SSBH will once again host a live lecture format for the joint symposium of KSBMR-ASBMR-JSBMR. Invited are three researchers, each representing their respective society, to share the latest insights on bone metabolism research, particularly on the basic research of skeletal aging. Dr. Ok Hee Jeon, representing KSBMR, has been researching the musculoskeletal system and cartilage's aging process since completing her postdoctoral training at Buck Institute for Research on Aging and joining Korea University College of Medicine. She is an active junior member of the KSBMR Scientific Committee and will present new data on the aging/regeneration process of the musculoskeletal system based on blood sharing between two mice, following her recent publication in Nature Endocrinology. Dr. Noriaki Ono, representing ASBMR, is a musculoskeletal stem cell researcher who completed his postdoctoral fellowship under Dr. Henry Kronenberg at Harvard Medical School. He recently relocated his laboratory from the University of Michigan School of Dentistry to the University of Texas and has published many high-profile papers on musculoskeletal stem cells. He will present new data on the differences between periosteal stem cells of young mice and those of aging mice at this symposium. Dr. Sumito Ogawa, representing JSBMR, will discuss the clinical aspects of age-related muscle loss, frailty, and prevention methods. With the joint symposium held in person due to COVID, it is expected that higher-level lectures and discussions can take place.

Chair(s): Mary L. Bouxsein (Massachusetts General Hospital, USA), Seiji Fukumoto (The University of Tokushima, Japan)

13:25-13:50	Heterochronic Blood Exchange: Triggers Aging in Musculoskeletal System Ok Hee Jeon (Korea University, Korea)
13:50-14:15	Bone Marrow Endosteal Stem/Stromal Cells in Young Bones: An Essential Regulator of Bone Health and Disease Noriaki Ono (University of Texas at Houston School of Dentistry, USA)
14:15-14:40	Age-Related Sarcopenia and Frailty with Its Preventive Approaches Sumito Ogawa (Tokyo University, Japan)

Day 2 May 19(Fri) 13:25-14:40	Working Group 3. Nutrition Working Group K Bioactive Compounds of Food and Bone Metabolism Room 3

Chair(s): Yongsoon Park (Hanyang University, Korea)

13:25-13:50	Dual Action of Zinc in Osteogenic and Vascular Calcification In-Sook Kwun (Andong National University, Korea)
13:50-14:15	Development of Probiotics for Improving Menopausal Symptom and Bone Health Yun Tai Kim (Korea Food Research Institute, Korea)
14:15-14:40	Functional Food Materials for Musculoskeletal Health Jiyun Ahn (Korea Food Research Institute, Korea)

Day 2 May 19(Fri) 13:25-14:40	Working Group 4. Fracture Working Group K Room 4

Chair(s): Sung Bae Park (Seoul National University, Korea), Jae-Hwi Nho (Soonchunhyang University, Korea)

13:25-13:40	Atypical Forearm Fracture Associated with Bisphosphonate Usage Soo Min Cha (Chungnam National University, Korea)
13:40-13:55	Osteoporotic Fractures of the Knee: Prevention and Treatment Yong-Geun Park (Jeju National University, Korea)
13:55-14:10	Material for the Vertebroplasty of the Osteoporotic Vertebral Compression Fracture Je Hoon Jeong (Soonchunhyang University, Korea)
14:10-14:25	Efficacy of Osteoporosis Medication in the Conservative Treatment of Osteoporotic Vertebral Compression Fracture Ikchan Jeon (Yeungnam University, Korea)
14:25-14:40	Q&A

Day 2 May 19(Fri) 14:40-15:30	Plenary Lecture 2 E Room 1

Professor Steven R. Cummings is currently Director of San Francisco Coordinating Center and Emeritus Professor of Medicine, Epidemiology and Biostatistics at University of California, San Francisco. He is an internationally recognized expert on the epidemiology of osteoporosis, women's health, and aging. Goal-directed treatment, also called treat to target, is a strategy that has a clear goal and changes treatment if the goal is not achieved. Recently, it has been proposed as a strategy to assist clinicians in selecting the most appropriate initial treatment for osteoporosis and guiding subsequent decisions to continue, change, or stop treatment. In this plenary session, he will give us an informative lecture about goal-directed treatment for osteoporosis.

Chair(s): Ho-Yeon Chung (Kyung Hee University, Korea)

14:40-15:30	Goal-Directed Treatment for Osteoporosis Steven R. Cummings (San Francisco Coordinating Center, California Pacific Medical Center Research Institute, USA)

Day 2 May 19(Fri) 15:45-17:00	Symposium 3. KSBMR-NHIS Joint Symposium K Room 1

Chair(s): Soon-Ae Shin (NHIS, Korea), Yong-Chan Ha (Bumin Hospital, Korea)

15:45-16:00	Method and Result of Osteoporosis Fracture Treatment Episode Construction Jaiyong Kim (National Health Insurance Service, Korea)
16:00-16:15	Trends of Osteoporotic Fracture in South Korea Young-Kyun Lee (Seoul National University, Korea)
16:15-16:30	COVID-19 and Osteoporotic Fracture HoeJeong Chung (Yonsei University Wonju College of Medicine, Korea)
16:30-16:45	Status in the Treatment of Osteoporosis and Osteoporotic Fracture Kyoung Min Kim (Yonsei University, Korea)
16:45-17:00	Q&A

Day 2 May 19(Fri) 15:45-17:00	Symposium 4. Keynote Symposium E Integration of Informatics and Biology for Advanced Drug Development Room 2

In this section, we introduce three speakers from Korea and consisted of topics on advanced drug development using artificial intelligence and machine learning, which are the critical core techniques of recent drug development. Dr. Geun-Woo Lee of Angel-I-Drug Design will introduce the overall methodology of using artificial intelligence techniques for drug design under the theme of “In silico drug design: Overview and application”. Dr. Jeong-ah Kim of the Korea Basic Science Institute will introduce the application of artificial intelligence for musculoskeletal drug evaluation based on a recently published paper on the topic of “from biomimetic bone-on-a-chip to artificial intelligence: powerful tools for drug testing”. Lastly, Professor Dong-ryeol Ryu of Gwangju Institute of Science and Technology will take time to introduce the machine learning-based drug development method, focusing on the experience of using it in the actual drug development process, on the topic of “Sharing a wet lab biologist' experience with machine learning-based research”. Through this session, we hope that artificial intelligence and machine learning techniques, which have recently been attracting attention in the field of drug development, will provide an opportunity to directly experience the latest research methodologies and practical application cases for use in the musculoskeletal field.

Chair(s): Gun-Il Im (Dongguk University, Korea), Je-Yong Choi (Kyungpook National University, Korea)

15:45-16:10	In Silico Drug Design Study for Drug & PROTAC Design Keun Woo Lee (Angel i-Drug Design (AiDD), Korea)
16:10-16:35	From Biomimetic Bone-on-a-chip to Artificial Intelligence: Powerful Tools for Drug Testing Jeong Ah Kim (Korea Basic Science Institute, Korea)
16:35-17:00	Sharing a Wet Lab Biologist's Experiences with Machine Learning-Based Research Dongryeol Ryu (GIST, Korea)

Day 2 May 19(Fri) 15:45-16:35	Meet the Expert 2 E Room 3

15:45-16:35	Spaceflight and Bone Health Mary L. Bouxsein (Massachusetts General Hospital, USA)

Scientific Program